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Title: |
Streptozotocin |
| Sub-title: |
Uses, Mechanism of Action & Side Effects |
Search Result:
| Edited by: |
Elizabeth L Gauthier |
| ISBN10-13: |
1631172557 : 9781631172557 |
| Format: |
Hardback |
| Size: |
260x180mm |
| Pages: |
170 |
| Weight: |
.466 Kg. |
| Published: |
Nova Science Publishers, Inc (US) - May 2014 |
| List Price: |
163.99 Pounds Sterling |
| Availability: |
Temporarily Out of Stock, more expected soon
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| Subjects: |
Medicine: general issues |
| Streptozotocin (STZ), an antibiotic and anticancer agent, is the most prominent diabetogenic chemical agent in diabetes research due to its cytotoxicity in pancreatic beta-cells. The selective toxicity of STZ to beta cells occurs because of its preferential accumulation in beta cells through uptake via GLUT2 glucose transporter. Insulin dependent diabetes mellitus can be induced by either single high dose or multiple low-dose STZ injections. At low dose, STZ induces pancreatic beta-cell apoptosis and at high dose it causes necrosis. Though STZ itself can cause carcinogenesis and renal, hepatic and muscle myoblast toxicity, these side effects can be minimised or completely avoided by using lower doses. This book discusses in further detail the different ways in which streptozotocin is used in the medical field. |
| Table of Contents: |
| Streptozotocin as a Tool to Induce Central Pathology & Cognitive Impairment in Rodents; Use of Streptozotocin in Experimental Type 1 Diabetic Models; Cognitive Impairment Induced by Streptozotocin: An Experimental Link between Diabetes & Alzheimer’s Disease; Streptozotocin-Induced Rodent Models of Diabetes: Protocol Comparisons; Matrix Metalloproteases in Streptozotocin Model of Diabetes Mellitus; Genotoxic Effects of Streptozotocin; Toxic Effect of Streptozotocin (STZ) on the Hepatobiliary Function: Oxidative Stress & Inflammation may Contribute to the Hepatic Complications During STZ-Induced Insulin-Dependent Diabetes.
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