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Title: Reassessing HIV Vaccine Design & Approaches
Sub-title: Towards a Paradigm Shift
Edited by: Omar Bagasra, Donald Gene Pace
ISBN10-13: 1622579526 : 9781622579525
Format: Hardback
Size: 260x180mm
Pages: 369
Weight: .718 Kg.
Published: Nova Science Publishers, Inc (US) - May   2013
List Price: 252.99 Pounds Sterling
Availability: Temporarily Out of Stock, more expected soon 
Subjects: HIV / AIDS : Medical microbiology & virology
Why do we not have a vaccine for HIV? What are we doing wrong? Every HIV vaccine has failed so far, and public opinion is turning pessimistic against the scientific community. HIV vaccine efforts need a major shift in strategy. They require a better understanding of the immunological mechanisms that prevent African primates from getting AIDS. None of the 40 species of African primates, including chimpanzees and gorillas, get AIDS, even though all of them carry HIV-like viruses in their bodies. Why are they "naturally vaccinated," while all of the man-made vaccines against HIV have failed miserably? This book offers intriguing new possibilities for the nature of human immunity, and the development of an effective AIDS vaccine. It is also a provocative treatise on the origin, evolution, and etiology of several forms of immune systems that is supported by a wealth of peer-reviewed scientific references. The compelling ideas presented in this study should have an important bearing on HIV vaccine development. It is a must read for anyone interested in the development of a safe AIDS vaccine, and for individuals interested in human immunity generally.
Table of Contents:
Preface; A Shift in the Current Concept of HIV Vaccine; Immunity: Old Paradigm Versus New; The Architecture of the Classical Immune System; Origins of HIV-1; A Unified Concept of HIV Latency, Persistence & Reservoirs; Immune Activation & MicroRNA; GBV-C: A Natural HIV Interfering Virus; HIV Prevention & Compounding Factors in Chronic Progression to AIDS; Epilogue; References; Index.
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