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Title: |
Serpins & Protein Kinase Inhibitors |
| Sub-title: |
Novel Functions, Structural Features & Molecular Mechanisms |
Search Result:
| Edited by: |
Bojidor Georgiev, Sava Markovski |
| ISBN10-13: |
1607411873 : 9781607411871 |
| Illustrations: |
tables & charts |
| Format: |
Hardback |
| Size: |
180x260mm |
| Pages: |
257 |
| Weight: |
.704 Kg. |
| Published: |
Nova Science Publishers, Inc (US) - March 2010 |
| List Price: |
234.99 Pounds Sterling |
| Availability: |
Temporarily Out of Stock, more expected soon
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| Subjects: |
Biochemistry |
| Serpins, a group of proteins with similar structures, were first identified as a set of proteins able to inhibit proteases. The first members of the serpin superfamily to be extensively studied were the human plasma proteins antithrombin and antitrypsin, which play key roles in controlling blood coagulation and inflammation. Today, over 1000 serpins have been identified, including 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are thus the largest and most diverse family of protease inhibitors. In contrast, a protein kinase inhibitor is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Protein tyrosine kinases (PTKs) play a key role in the regulation of cell proliferation, differentiation, metabolism, migration and survival. Due to their involvement in various forms of cancer, PTKs have become prominent targets for therapy. This new book gathers the latest research from around the globe in this dynamic field. |
| Table of Contents: |
| Preface; Serpin-Related Diseases; The Roles of Mammalian Mitogen-Activated Protein Kinase-Activating Protein Kinases (MAPKAPKs) in Cell Cycle Control; Rho-Kinase Inhibitor in Kidney Disease; Targeting the Epidermal Growth Factor Receptor Pathway in Glioblastoma Multiforme and Other Intracranial Malignancies; The Serine Proteinase Inhibitor Z Alpha-1 Antitrypsin: Acting on the NF-kappaB System for Cytotoxicity; Src Family Kinase Inhibitors in Cancer Therapy; Protein Kinase Inhibitors in Cancer; Protein Kinase Inhibitors: New Research; PAI-1 and the Diet-Induced Obesity Phenotype: Background Effects and Inbreeding; The Structure of á1-Proteinase Inhibitor Polymer: Facts and Hypothesis; SERPINA5 Expression in the Male Reproductive Tract is altered with Advanced Age; Vaspin: Visceral Adipose Tissue-Derived Serpin with Insulin-Sensitizing Effects; Effect of Alpha2-antiplasmin on Tissue Remodeling; Index. |
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